George Kennedy was furious that he missed the chance to spoof himself in this movie. He would later get that opportunity in the Naked Gun series.

In his autobiography, Christopher Lee states that he turned down the role of Dr. Rumack.

David Letterman screen tested for the role of Ted Striker. Jerry Zucker later brought the tape along to a Late Night appearance. Dave was not amused.

Barry Manilow was reportedly considered to play Ted Striker.

The role of Murdock (Kareem Abdul-Jabbar) was originally going to go to Pete Rose.

Jack Webb turned down a role in this movie.

Willard turned down the role of Ted Striker.

Efrem Zimbalist, Jr. turned down a role in Airplane! according to the DVD commentary.