Holly Hunter turned down the lead in "As Good as it Gets" because she objected to the age difference between her character and Jack Nicholson.
Holly Hunter was considered to play the lead. She turned the part down and her (then) roommate Frances McDormand took the role.
Holly Hunter was the first choice to play God.
Sam Raimi had Holly Hunter in mind for the part.
She, along with Frances McDormand, were screenwriter Callie Khouri's choices to play Thelma and Louise.

Did you know that Holly Hunter was not the only choice for these movies?
(click to learn more)